A centriolar lifeline

Centriolar Satellites

We identified Xenopus pericentriolar material-1 (PCM-1), which had been reported to constitute pericentriolar material, cloned its cDNA, and generated a specific pAb against this molecule. Immunolabeling revealed that PCM-1 was not a pericentriolar material protein, but a specific component of centriolar satellites, morphologically characterized as electron-dense granules, approximately 70-100 ...

A lifeline for primary care.

n engl j med 360;26 nejm.org june 25, 2009 2693 levels.1 Overloaded primary care practices, whose doctors are aptly compared to hamsters on a treadmill, struggle to provide prompt access and high-quality care. Three major factors contribute to this crisis. First, primary care physicians earn far lower incomes than procedural specialists, reducing career attractiveness for medical students with ...

A lifeline for battering parents.

A lifeline for lipid rafts?

In Focus • THE JOURNAL OF CELL BIOLOGY S o far, defi nitive proof of the existence of lipid rafts in vivo has slipped through researchers’ fi ngers. Although their results probably won’t settle the debate over whether such structures exist, Toulmay and Prinz reveal that yeast produce raft-like domains in a surprising place (1). The original raft hypothesis held that the plasma membrane harbors ...

Centriolar inequality

N ot all centrosomes are created equal. On page 13, Rusan and Peifer reveal that the separation of a dominant and a secondary centrosome helps defi ne an asymmetric division axis in fl y neuroblasts. Asymmetric divisions in stem cells give rise to one daughter that will differentiate and one that will replace the stem cell. This asymmetry can be set by the orientation of the mitotic spindle thr...